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Magnetic Resonance An interactive open-access publication of the Groupement AMPERE
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Preprints
https://doi.org/10.5194/mr-2020-27
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-2020-27
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

  05 Nov 2020

05 Nov 2020

Review status
This preprint is currently under review for the journal MR.

Open-source, 3D-printed, high-pressure (50 bar) liquid-nitrogen-cooled para-hydrogen generator

Frowin Ellermann, Andrey Pravdivtsev, and Jan-Bernd Hövener Frowin Ellermann et al.
  • Section for Biomedical Imaging, Molecular Imaging North Competence Center (MOIN CC), Department of Radiology and Neuroradiology, University Medical Center Schleswig-Holstein (UKSH), Kiel, 24118, Germany

Abstract. The signal of magnetic resonance imaging (MRI) can be enhanced by several orders of magnitude using hyperpolarization. In comparison to a broadly used Dynamic Nuclear Polarization (DNP) technique that is already used in clinical trials, the para-hydrogen (pH2) based hyperpolarization approaches are less cost-intensive, scalable and offer high throughput. However, a pH2 generator is necessary. Available commercial pH2 generators are relatively expensive (10,000–150,000 €). To facilitate the spread of pH2 hyperpolarization studies, here, we provide the blueprints and 3D-models as open-source for a low-cost (< 3,000 €) 50 bar liquid nitrogen pH2 generator.

Frowin Ellermann et al.

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Frowin Ellermann et al.

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Latest update: 01 Dec 2020
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Short summary
Modern contrast agents for MRI lead to new methods for e.g. cancer diagnosis. One of these promising methods is called PHIP (Para-Hydrogen Induced Polarization) and can be performed at low instrumentation costs. However, it is based on para-hydrogen which has to be produced on-site. Since commercial generators cost up to 150,000 €, we decided to provide the blueprints of our generator (< 3,000 €) as open-source to enable more groups to build their own generator and enter this research field.
Modern contrast agents for MRI lead to new methods for e.g. cancer diagnosis. One of these...
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