Preprints
https://doi.org/10.5194/mr-2021-1
https://doi.org/10.5194/mr-2021-1

  20 Jan 2021

20 Jan 2021

Review status: a revised version of this preprint is currently under review for the journal MR.

Exploration of the close chemical space of tryptophan and tyrosine reveals importance of hydrophobicity in photo-CIDNP performances

Felix Torres, Alois Renn, and Roland Riek Felix Torres et al.
  • Laboratory of Physical Chemistry, ETH Zurich, Zuerich, 8093, Switzerland

Abstract. Sensitivity being one of the main hurdles of Nuclear Magnetic Resonance (NMR) can be gained by polarization techniques including Chemical Induced Dynamic Nuclear Polarization (CIDNP). Kaptein demonstrated that in CIDNP the polarization arises from the formation and the recombination of a radical pair in a magnetic field. In photo-CIDNP of interest here the radical pair is between a dye and the molecule to be polarized. The polarization obtained is thereby dependent on a complex interplay between the two molecules and their physico chemical properties. Here, we explore photo-CIDNP with a set of ten tryptophan and tyrosine analogs and observe not only signal enhancement of two orders of magnitude for 1H at 600 MHz (corresponding to 10'000 times in measurement time), but also reveal that the hydrophobicity of the molecule appears to be an important factor in the polarisation extend. Furthermore, the small chemical library established indicate the existence of many photo-CIDNP active molecules.

Felix Torres et al.

Status: final response (author comments only)

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • CC1: 'Comment on mr-2021-1', Peter Hore, 21 Jan 2021
    • AC1: 'Reply on CC1', Roland Riek, 21 Jan 2021
  • RC1: 'Comment on mr-2021-1', Peter Hore, 25 Jan 2021
  • RC2: 'Comment on mr-2021-1', Anonymous Referee #2, 12 Feb 2021
    • AC2: 'Reply on RC2', Roland Riek, 19 Feb 2021

Felix Torres et al.

Felix Torres et al.

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Short summary
Derivatives of the amino acids tryptophan and tyrosine were studied in their potential to enhance their signal in nuclear magnetic resonance spectroscopy (NMR) by laser-induced dynamic nuclear polarisation (CIDNP). Signal enhancement up to two orders of magnitude was obtained.