Preprints
https://doi.org/10.5194/mr-2021-11
https://doi.org/10.5194/mr-2021-11

  04 Feb 2021

04 Feb 2021

Review status: this preprint is currently under review for the journal MR.

Overhauser Dynamic Nuclear Polarization Enhanced Two-Dimensional Proton NMR Spectroscopy at Low Magnetic Fields

Timothy J. Keller and Thorsten Maly Timothy J. Keller and Thorsten Maly
  • Bridge12 Technologies Inc., 37 Loring Drive, Framingham, MA 01702, USA

Abstract. The majority of low-field Overhauser Dynamic Nuclear Polarization (ODNP) experiments reported so far have been 1D NMR experiments to study hydration dynamics. In this work, we demonstrate the application of ODNP-enhanced 2D J-resolved (JRES) spectroscopy to improve spectral resolution beyond the limit imposed by the line broadening introduced by the paramagnetic polarizing agent. Using this approach, we are able to separate the overlapping multiplets of ethyl crotonate into a 2nd dimension and clearly identify each chemical cite individually. Crucial to these experiments is interleaved spectral referencing, a method introduced to compensate for temperature induced field drifts over the course of the NMR acquisition. This method does not require additional hardware such as a field-frequency lock, which is especially challenging when designing compact systems.

Timothy J. Keller and Thorsten Maly

Status: open (until 09 Mar 2021)

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-11', Anonymous Referee #1, 13 Feb 2021 reply
  • RC2: 'Comment on mr-2021-11', Gunnar Jeschke, 22 Feb 2021 reply

Timothy J. Keller and Thorsten Maly

Timothy J. Keller and Thorsten Maly

Viewed

Total article views: 221 (including HTML, PDF, and XML)
HTML PDF XML Total Supplement BibTeX EndNote
166 52 3 221 16 1 2
  • HTML: 166
  • PDF: 52
  • XML: 3
  • Total: 221
  • Supplement: 16
  • BibTeX: 1
  • EndNote: 2
Views and downloads (calculated since 04 Feb 2021)
Cumulative views and downloads (calculated since 04 Feb 2021)

Viewed (geographical distribution)

Total article views: 178 (including HTML, PDF, and XML) Thereof 178 with geography defined and 0 with unknown origin.
Country # Views %
  • 1
1
 
 
 
 
Latest update: 26 Feb 2021
Download
Short summary
Typically, low-field Overhauser Dynamic Nuclear Polarization (ODNP) experiments are 1D NMR experiments to study hydration dynamics. Here, we demonstrate the application of ODNP-enhanced 2D J-resolved (JRES) spectroscopy to improve spectral resolution beyond the limit imposed by the line broadening introduced by the paramagnetic polarizing agent. Crucial to these experiments is interleaved spectral referencing to compensate for temperature induced field drifts over the course of the experiment.