Preprints
https://doi.org/10.5194/mr-2021-36
https://doi.org/10.5194/mr-2021-36

  01 Apr 2021

01 Apr 2021

Review status: this preprint is currently under review for the journal MR.

Mechanisms of coherent re-arrangement for long-lived spin order

Florin Teleanu1,2 and Paul R. Vasos1,2,3 Florin Teleanu and Paul R. Vasos
  • 1Extreme Light Infrastructure - Nuclear Physics ELI-NP, Laser Gamma Experiments Department (LGED), “Horia Hulubei” National Institute for Physics and Nuclear Engineering IFIN-HH, 30 Reactorului Street, RO-077125 Bucharest-Măgurele, Romania
  • 2Interdisciplinary School of Doctoral Studies, University of Bucharest
  • 3University of Bucharest, B-dul Regina Elisabeta, Bucharest, Romania

Abstract. Long-lived spin order-based approaches for magnetic resonance rely on the transition between two magnetic environments of different symmetry, one governed by the magnetic field of the spectrometer and the other where this strong magnetic field is inconsequential. Research on the excitation of magnetic-symmetry transitions in nuclear spins is a scientific field that debuted in Southampton in the years 2000. We advanced in this field carrying the baggage of pre-established directions in NMR spectroscopy. We propose to reveal in this text the part of discoveries that may have been obscured by our choice to only look at them through the experience of such pre-established directions, at the time. Focussing on potential applications, we may have insufficiently emphasised in the manuscripts the methodological developments that necessitated most scientific effort. Such methods developments foster most of the progress in NMR. Thus, we present the contributed mechanisms of translation between the symmetric and non-symmetric environments with respect to the main magnetic field B0, free of any utilitarian perspective. The concept of zero-quantum rotations in the starting blocks of long-lived state populations, magnetisation transfers between hyperpolarised heteronuclei and protons, and selective inversion for long-lived coherences are discussed, as well as hybrid 2D methods based on both insensitive nuclei excitation (“INEPT”) and long-lived spin order. We can see at this point that these magnetic wheels will take a longer time than we initially thought to set in motion new applications in studies of slow diffusion, angiography, or large-protein structure. However, these pulse sequences seed subsequent magnetic mechanisms that are sure to contribute to applications. For instance, some of the introduced coherence rotations were combined with classical pulse blocks to obtain 2D correlations between protons and heteronuclei. We hope the pulse sequence building blocks discussed herein open further perspectives for magnetic resonance experiments with long-lived spin order.

Florin Teleanu and Paul R. Vasos

Status: final response (author comments only)

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-36', Malcolm Levitt, 19 Apr 2021
    • AC1: 'Reply on RC1', Paul Vasos, 23 May 2021
  • CC1: 'Comment on mr-2021-36', Geoffrey Bodenhausen, 21 Apr 2021
    • AC2: 'Reply on CC1', Paul Vasos, 23 May 2021
  • RC2: 'Comment on mr-2021-36', Thomas Eykyn, 05 May 2021
    • AC3: 'Reply on RC2', Paul Vasos, 23 May 2021

Florin Teleanu and Paul R. Vasos

Florin Teleanu and Paul R. Vasos

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Short summary
Long-lived nuclear spin order overcomes the limited timescale of polarization storage by displaying much longer lifetimes compared to the longitudinal and transversal magnetizations. However, the excitation of these symmetry-adapted states required spin choreographies that were often overshadowed by their applications. Here, we recapitulate some of the milestones achieved in designing suited pulse sequences and comment on some future perspectives.