Preprints
https://doi.org/10.5194/mr-2021-56
https://doi.org/10.5194/mr-2021-56

  16 Jul 2021

16 Jul 2021

Review status: this preprint is currently under review for the journal MR.

Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment

Neil MacKinnon1, Mehrdad Alinaghian1, Pedro Silva1,2, Thomas Gloge3, Burkhard Luy3, Mazin Jouda1, and Jan G. Korvink1 Neil MacKinnon et al.
  • 1Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany
  • 2DeepSpin GmbH, Kurfürstenstraße 56, 10785 Berlin
  • 3Institute of Biological Interfaces (IBG-4), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany

Abstract. Band selectivity to address specific resonances in a spectrum enables one to encode individual settings for diffusion experiments. In a single experiment, this could include different gradient strengths (enabling coverage of a larger range of diffusion constants), different diffusion delays, or different gradient directions (enabling anisotropic diffusion measurement). In this report a selective variant of the bipolar pulsed gradient, eddy-current delay (BPP-LED) experiment enabling selective encoding of three resonances was implemented. As proof-of-principle, the diffusion encoding gradient amplitude was assigned a range dependent on the selected signal, thereby allowing the extraction of the diffusion coefficient for water and a tripeptide (Met-Ala-Ser) with optimal settings in a single experiment.

Neil MacKinnon et al.

Status: final response (author comments only)

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • CC1: 'Comment on mr-2021-56', R. Soong, 16 Jul 2021
  • RC1: 'Comment on mr-2021-56', Davy Sinnaeve, 03 Aug 2021
  • RC2: 'Comment on mr-2021-56', Anonymous Referee #2, 06 Aug 2021
  • AC1: 'Comment on mr-2021-56', Neil MacKinnon, 15 Sep 2021

Neil MacKinnon et al.

Neil MacKinnon et al.

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Short summary
To increase experimental efficiency, information can be encoded in parallel by taking advantage of highly resolved NMR spectra. Here we demonstrate parallel encoding of optimal diffusion parameters by selectively using a resonance for each molecule in the sample. This yields a factor of n decrease in experimental time since n experiments can be encoded into a single measurement. This principle can be extended to additional experimental parameters as a means to further improve measurement time.