08 May 2023
 | 08 May 2023
Status: this preprint is currently under review for the journal MR.

Cryogenic-Compatible Spherical Rotors and Stators for Magic Angle Spinning Dynamic Nuclear Polarization

Lauren E. Price, Nicholas Alaniva, Marthe Millen, Till Epprecht, Michael Urban, Alexander Däpp, and Alexander B. Barnes

Abstract. Cryogenic magic-angle spinning (MAS) is a standard technique utilized for Dynamic Nuclear Polarization (DNP) in solid state nuclear magnetic resonance (NMR). Here we describe the optimization and implementation of a stator for cryogenic MAS with spherical rotors, allowing for DNP experiments on large sample volumes. Designs of the stator and rotor for cryogenic MAS build on recent advancements of MAS spheres, and take a step further to incorporate sample-insert/eject and temperature-independent spinning stability of +/- 1 Hz. At a field of 7 T and spinning at 2.0 kHz with a sample temperature of 105–107 K, DNP enhancements of 256 and 200 were observed for 124 μL and 223 μL sample volumes, respectively, each consisting of 4 M 13C, 15N-labelled urea and 20 mM AMUPol in a glycerol-water glassy matrix.

Lauren E. Price et al.

Status: open (until 05 Jun 2023)

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2023-6', Kong Ooi Tan, 11 May 2023 reply
  • RC2: 'Comment on mr-2023-6', Ilia Kaminker, 25 May 2023 reply

Lauren E. Price et al.

Lauren E. Price et al.


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Short summary
This paper describes the design and implementation of new technology for nuclear magnetic resonance which is a technique used to understand molecular structure and dynamics of many systems. The spherical sample container and its apparatus introduced in this paper is used to perform initial proof of principle experiments at cryogenic temperatures. Further development of this technology will facilitate more flexibility in magnetic resonance experiments.