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https://doi.org/10.5194/mr-2025-7
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-2025-7
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Preprints
19 Jun 2025
 | 19 Jun 2025
Status: this preprint is currently under review for the journal MR.

Long-Lived States Involving a Manifold of Fluorine-19 Spins in Fluorinated Aliphatic Chains

Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, and Geoffrey Bodenhausen

Abstract. Long-lived states (LLS) have lifetimes TLLS that exceed longitudinal spin-lattice relaxation times T1. In this study, lifetimes TLLS (19F) have been measured in three different achiral per- and polyfluoroalkyl substances (PFAS) containing 2 or 3 consecutive CF2 groups. In a static magnetic field B0 = 11.6 T, the lifetimes TLLS(19F) exceed the longitudinal relaxation times T1(19F) by about a factor of 3. The lifetimes TLLS(19F) can be strongly affected by binding to macromolecules, a feature that can be exploited for the screening of fluorinated drugs. Both TLLS(19F) and T1(19F) should be longer at low fields where relaxation due to the chemical shift anisotropy (CSA) of 19F is less effective, as will be shown elsewhere.

How to cite. Wiame, C., Van Dyck, S., Sheberstov, K., Razanahoera, A., and Bodenhausen, G.: Long-Lived States Involving a Manifold of Fluorine-19 Spins in Fluorinated Aliphatic Chains, Magn. Reson. Discuss. [preprint], https://doi.org/10.5194/mr-2025-7, in review, 2025.
Received: 05 Jun 2025 – Discussion started: 19 Jun 2025

Competing interests: At least one of the (co-)authors is a member of the editorial board of Magnetic Resonance.

Publisher's note: Copernicus Publications remains neutral with regard to jurisdictional claims made in the text, published maps, institutional affiliations, or any other geographical representation in this preprint. The responsibility to include appropriate place names lies with the authors.
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Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, and Geoffrey Bodenhausen

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Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, and Geoffrey Bodenhausen
Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, and Geoffrey Bodenhausen

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Short summary
In achiral PFAS with 2–3 CF₂ groups, long-lived ¹⁹F spin states (TLLS) were measured and found to last about 3× longer than T₁ in a static 11.6 T field. These lifetimes are sensitive to macromolecular binding, making them useful for screening fluorinated drugs. TLLS and T₁ are expected to increase at lower fields where ¹⁹F CSA effects are weaker.
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