To enhance small molecule NMR structure elucidation strategies, we screened four paramagnetic co-solutes for signal-to-noise enhancement. Chromium (III) improved signal-to-noise by up to 4.5 X, allowing quality data collection in about one-quarter of the time. Benefits were greatest for carbon atoms without attached hydrogen but varied between molecules. This simple approach could help assign difficult molecular structures for specialist and non-specialist NMR users.

The analysis of magic-angle spinning nuclear magnetic resonance experiments often includes determining a constant effective replacement for a periodic time-dependent Hamiltonian. We provide a clarifying overview over the two most used approaches, covering their mathematical origin, context, and relationship to each other, as well as their practical use for nuclear magnetic resonance applications. We recommend Floquet theory due to its numerical robustness, efficiency and accuracy.