To enhance small molecule NMR structure elucidation strategies, we screened four paramagnetic co-solutes for signal-to-noise enhancement. Chromium (III) improved signal-to-noise by up to 4.5 X, allowing quality data collection in about one-quarter of the time. Benefits were greatest for carbon atoms without attached hydrogen but varied between molecules. This simple approach could help assign difficult molecular structures for specialist and non-specialist NMR users.