Recent  

Dynamic nuclear polarisation (DNP) transfers polarisation from electron to nuclear spins. This is usually combined with direct detection of the latter. Here, we show that it is possible to reverse the transfer at 1.2 T. This allows us to investigate the spin dynamics of nuclear spins close to electrons – something that is notoriously difficult with established methods. We expect reverse DNP to be useful in the study of spin diffusion or as a building block for more elaborate pulse sequences.

We present a generalized measurement-based 3D-visualization approach for describing dynamics in strongly coupled spin ensembles. The visualized surfaces conveniently represent symmetries of density matrices and allow spotting of their presence (orientation, alignment, etc.) or absence even when direct analysis of density matrices is not obvious. We apply a novel visualization approach to represent relevant cases of 2-spin system dynamics.

A straightforward, rather accurate approach to extract quantitative restraints for the structure calculation of ligand–protein complexes is presented.

In this article we report a multiscale approach for explaining why the transport of fluids in oil shales is so hindered. Thanks to nuclear and electronic magnetic resonances, we first demonstrate that the kerogen within the shale is capable of swelling in the presence of oil; and second we show that this swelling is reversible and reveals the presence of vanadyl porphyrin by breaking magnetic interaction. The magnetic interactions evidenced helps understand the very low mobility of hydrocarbons.

Egyptian mummies were covered with an enigmatic black organic matter. Its chemical composition is classically determined by molecular analysis methods, which are destructive by nature. In a new analytical approach based on 1H and 14N hyperfine spectroscopy, we use V⁺ ions, existing at trace level in this black matter, as internal probes for a non-destructive exploration of the material. The results suggest that a common recipe was used for animal and human mummies of different ages.

This work examines the physics underlying double electron–electron resonance (DEER) spectroscopy, a magnetic-resonance method that provides nanoscale data about protein structure and conformations.

We show here that binding of the anticancer drug imatinib to the ATP site of Abelson kinase and not binding to its allosteric site coincides with the opening of the kinase regulatory core at nanomolar concentrations. This has implications for the understanding of Abelson’s kinase regulation and activity during medication as well as for the design of new Abelson kinase inhibitors.

We have presented a CMOS-based NMR platform featuring arbitrary phase control and coherent detection in a non-zero intermediate frequency (IF) receiver architecture as well as active automatic temperature compensation. The proposed platform is centered around a custom-designed NMR-on-a-chip transceiver. The entire system achieves a phase stability well below 1° in consecutive pulse acquire experiments and keeps a normalized standard deviation in the measured T2 values of 0.45 % over 100 min.

Installing a tag containing a paramagnetic metal ion on a protein can lead to large changes (pseudocontact shifts) in the resonances observed in NMR spectra. These are easily measured and contain valuable long-range structural information. The present work shows that a single tagging site furnished with different tags can be sufficient to localise atoms in proteins with high accuracy. In fact, this strategy works almost as well as the same number of tags distributed over multiple tagging sites.