In achiral polyfluoroalkyl substances with two to three CF₂ groups, long-lived ¹⁹F spin states (T_LLS) were measured and found to last about three times longer than T₁ in a static 11.6 T field. These lifetimes are sensitive to macromolecular binding, making them useful for screening fluorinated drugs.

The small protein GB1, where all valine residues were replaced by fluorinated analogues containing one or two CH₂F groups, produces ¹⁹F NMR (nuclear magnetic resonance) spectra with exceptional resolution. We establish a convenient strategy for their assignment and analyse the rotameric states of the CH₂F groups by virtue of three-bond coupling constants and a γ effect on ¹³C chemical shifts, which is underpinned by DFT (density functional theory) calculations. Transient fluorine–fluorine contacts are documented by through-space ¹⁹F–¹⁹F couplings.

By reviewing attendee lists of 10 MR (magnetic resonance) meetings over the last year, we estimate the climate footprint of conferences and explore possibilities to reduce it. This paper will facilitate discussions about possible actions the community may take.

Investigating NMR (nuclear magnetic resonance) phenomena at variable magnetic fields is useful and insightful for hyperpolarization and molecular dynamics in particular. To benefit from high-resolution at high magnetic fields, field-dependent investigations can be performed using a high-field NMR spectrometer, with a sample shuttle apparatus for field cycling. Here, we introduce a new design of a sample shuttle which is fast, reliable, and narrow. We show a series of applications involving small molecules and a protein in solution.