Relaxation-induced dipolar exchange with recoupling (RIDER) distortions in CODEX experiments

Krushelnitsky, Alexey; Saalwächter, Kay

doi:https://doi.org/10.5194/mr-1-247-2020

Articles | Volume 1, issue 2

https://doi.org/10.5194/mr-1-247-2020

© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/mr-1-247-2020

© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 1, issue 2

Research article

|

29 Oct 2020

Research article |

| 29 Oct 2020

Relaxation-induced dipolar exchange with recoupling (RIDER) distortions in CODEX experiments

Alexey Krushelnitsky and Kay Saalwächter

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Final revised paper (published on 29 Oct 2020)
Preprint (discussion started on 16 Sep 2020)

Interactive discussion

Status: closed

AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment

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- Supplement

RC1: 'manuscript report', Anonymous Referee #1, 02 Oct 2020
RC2: 'Comments on "RIDER Distortions in the CODEX experiments"', Anonymous Referee #2, 07 Oct 2020
AC1: 'Reply to the reviewer's comments', Alexey Krushelnitsky, 19 Oct 2020

Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision

AR by Svenja Lange on behalf of the Authors (22 Oct 2020) Author's response

ED: Publish as is (22 Oct 2020) by Perunthiruthy Madhu

Short summary

This work presents systematic methodological study of one of the types of the nuclear magnetic resonance experiments that enables study of molecular dynamics on a millisecond timescale. A modification of a standard experiment was suggested that excludes possible artefacts and distortions. It has been demonstrated that the standard experiment reveals slow overall motion of proteins in a rigid crystal lattice, whereas the artefact-free experimental setup demonstrates that the proteins are rigid.