Magnetic Resonance
Magnetic Resonance
MR
Articles | Volume 2, issue 1
Articles | Volume 2, issue 1
https://doi.org/10.5194/mr-2-355-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Special issue:
https://doi.org/10.5194/mr-2-355-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 2, issue 1
Research article
 | 
02 Jun 2021
Research article |  | 02 Jun 2021

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

Nestor Kamdem, Yvette Roske, Dmytro Kovalskyy, Maxim O. Platonov, Oleksii Balinskyi, Annika Kreuchwig, Jörn Saupe, Liang Fang, Anne Diehl, Peter Schmieder, Gerd Krause, Jörg Rademann, Udo Heinemann, Walter Birchmeier, and Hartmut Oschkinat

Viewed

Total article views: 2,059 (including HTML, PDF, and XML)
HTML PDF XML Total Supplement BibTeX EndNote
1,258 744 57 2,059 298 37 33
  • HTML: 1,258
  • PDF: 744
  • XML: 57
  • Total: 2,059
  • Supplement: 298
  • BibTeX: 37
  • EndNote: 33
Views and downloads (calculated since 25 Feb 2021)
Cumulative views and downloads (calculated since 25 Feb 2021)

Viewed (geographical distribution)

Total article views: 2,059 (including HTML, PDF, and XML) Thereof 1,852 with geography defined and 207 with unknown origin.
Country # Views %
  • 1
1
 
 
 
 

Cited

Latest update: 28 Sep 2023
Download
Short summary
The Wnt signalling pathway plays a major role in prevention of cancer, whereby the protein Dishevelled connects from the transmembrane receptor Frizzled to downstream effectors via its PDZ domain. Here, cycles of chemical synthesis and structural biology are applied to develop PDZ ligands that block the Frizzled–Dishevelled interaction using NMR for screening, in ligand development, and for deriving structure–activity relationships. Cellular reporter assays demonstrate their efficacy.
Read more
Special issue
Robert Kaptein Festschrift