Articles | Volume 1, issue 2
https://doi.org/10.5194/mr-1-175-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-1-175-2020
© Author(s) 2020. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Research article
| 
07 Aug 2020
Research article |
| 07 Aug 2020
| 07 Aug 2020
Geminal parahydrogen-induced polarization: accumulating long-lived singlet order on methylene proton pairs
Laurynas Dagys
School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK
Barbara Ripka
School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK
Markus Leutzsch
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
Gamal A. I. Moustafa
School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK
James Eills
Helmholtz Institute Mainz, Johannes Gutenberg University, 55099 Mainz, Germany
Johannes F. P. Colell
School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK
School of Chemistry, University of Southampton, Southampton SO17 1BJ, UK
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Cited
15 citations as recorded by crossref.
- Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid** L. Dagys et al. 10.1002/cphc.202200274
- Optimizing the Reaction Conditions for the Formation of Fumarate via Trans-Hydrogenation L. Wienands et al. 10.1007/s00723-021-01371-w
- Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes A. Pravdivtsev et al. 10.1021/acscatal.4c07870
- Singlet‐Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism** J. Eills et al. 10.1002/anie.202014933
- Spatially Resolved Kinetic Model of Parahydrogen Induced Polarisation (PHIP) in a Microfluidic Chip S. Ostrowska et al. 10.1002/cphc.202100135
- Nuclear singlet relaxation by chemical exchange C. Bengs et al. 10.1063/5.0066182
- Synergies between Hyperpolarized NMR and Microfluidics: A Review J. Eills et al. 10.1016/j.pnmrs.2021.09.001
- Hyperpolarized long-lived spin state of methylene protons of 2-bromoethanol obtained from ethylene with non-equilibrium nuclear spin order S. Babenko et al. 10.1016/j.jmr.2024.107648
- Markovian exchange phenomena in magnetic resonance and the Lindblad equation C. Bengs 10.1016/j.jmr.2020.106868
- Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip S. Barker et al. 10.1021/acs.analchem.1c05030
- Singulett‐Kontrast‐Magnetresonanztomographie: Freisetzung der Hyperpolarisation durch den Metabolismus** J. Eills et al. 10.1002/ange.202014933
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications B. Tickner & V. Zhivonitko 10.1039/D2SC00737A
- Spin Hyperpolarization in Modern Magnetic Resonance J. Eills et al. 10.1021/acs.chemrev.2c00534
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications M. Huynh & Z. Kovacs 10.1002/anse.202400044
- Geminal parahydrogen-induced polarization: accumulating long-lived singlet order on methylene proton pairs L. Dagys et al. 10.5194/mr-1-175-2020
14 citations as recorded by crossref.
- Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid** L. Dagys et al. 10.1002/cphc.202200274
- Optimizing the Reaction Conditions for the Formation of Fumarate via Trans-Hydrogenation L. Wienands et al. 10.1007/s00723-021-01371-w
- Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes A. Pravdivtsev et al. 10.1021/acscatal.4c07870
- Singlet‐Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism** J. Eills et al. 10.1002/anie.202014933
- Spatially Resolved Kinetic Model of Parahydrogen Induced Polarisation (PHIP) in a Microfluidic Chip S. Ostrowska et al. 10.1002/cphc.202100135
- Nuclear singlet relaxation by chemical exchange C. Bengs et al. 10.1063/5.0066182
- Synergies between Hyperpolarized NMR and Microfluidics: A Review J. Eills et al. 10.1016/j.pnmrs.2021.09.001
- Hyperpolarized long-lived spin state of methylene protons of 2-bromoethanol obtained from ethylene with non-equilibrium nuclear spin order S. Babenko et al. 10.1016/j.jmr.2024.107648
- Markovian exchange phenomena in magnetic resonance and the Lindblad equation C. Bengs 10.1016/j.jmr.2020.106868
- Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip S. Barker et al. 10.1021/acs.analchem.1c05030
- Singulett‐Kontrast‐Magnetresonanztomographie: Freisetzung der Hyperpolarisation durch den Metabolismus** J. Eills et al. 10.1002/ange.202014933
- Advancing homogeneous catalysis for parahydrogen-derived hyperpolarisation and its NMR applications B. Tickner & V. Zhivonitko 10.1039/D2SC00737A
- Spin Hyperpolarization in Modern Magnetic Resonance J. Eills et al. 10.1021/acs.chemrev.2c00534
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications M. Huynh & Z. Kovacs 10.1002/anse.202400044
1 citations as recorded by crossref.
Latest update: 30 Oct 2025
Short summary
We explored hydrogenation reaction with a para-spin isomer of a hydrogen molecule as a source of nuclear singlet state. As a product of this reaction, the state was populated between two protons of the methylene group. We have shown that, utilizing long-lived properties of such a nuclear spin state, a high nuclear spin polarization can be accumulated. To explain this effect we have given a kinetic model which could be potentially applied for similar schemes involving spin dynamics in chemistry.
We explored hydrogenation reaction with a para-spin isomer of a hydrogen molecule as a source of...
