Articles | Volume 2, issue 1
Research article
29 Jan 2021
Research article |  | 29 Jan 2021

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Giovanni Bellomo, Enrico Ravera, Vito Calderone, Mauro Botta, Marco Fragai, Giacomo Parigi, and Claudio Luchinat


Interactive discussion

Status: closed
Status: closed
AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment
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Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Claudio Luchinat on behalf of the Authors (08 Jan 2021)  Author's response    Manuscript
ED: Publish as is (11 Jan 2021) by Rolf Boelens

Post-review adjustments

AA: Author's adjustment | EA: Editor approval
AA by Claudio Luchinat on behalf of the Authors (26 Jan 2021)   Author's adjustment   Manuscript
EA: Adjustments approved (27 Jan 2021) by Rolf Boelens
Short summary
The efficiency of MRI contrast agents can increase by exploiting magnetization transfer effects occurring in slow-rotating nanoparticles containing a paramagnetic metal ion and a large number of exchangeable surface protons, which can increase the water proton relaxation rate. Occurrence of magnetization transfer should also be considered to determine accurate metal–proton distances from the experimental proton relaxation rates for protons farther than 15 Å from the paramagnetic metal.