Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Bellomo, Giovanni; Ravera, Enrico; Calderone, Vito; Botta, Mauro; Fragai, Marco; Parigi, Giacomo; Luchinat, Claudio

doi:https://doi.org/10.5194/mr-2-25-2021

Articles | Volume 2, issue 1

https://doi.org/10.5194/mr-2-25-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Special issue:

Robert Kaptein Festschrift

https://doi.org/10.5194/mr-2-25-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 2, issue 1

Research article

|

29 Jan 2021

Research article |

| 29 Jan 2021

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Giovanni Bellomo, Enrico Ravera, Vito Calderone, Mauro Botta, Marco Fragai, Giacomo Parigi, and Claudio Luchinat

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Final revised paper (published on 29 Jan 2021)
Supplement to the final revised paper
Preprint (discussion started on 03 Dec 2020)
Supplement to the preprint

Interactive discussion

Status: closed

AC: Author comment | RC: Referee comment | SC: Short comment | EC: Editor comment

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- Supplement

RC1: 'nuclear paramagnetic relaxation', Carlos Geraldes, 11 Dec 2020
- AC1: 'answer to the comment', Claudio Luchinat, 22 Dec 2020
SC1: 'What would the situation be like in the context of perdeuteration?', Gottfried Otting, 20 Dec 2020
- AC2: 'answer to the comment', Claudio Luchinat, 22 Dec 2020
  - SC2: 'useful software', Gottfried Otting, 23 Dec 2020
    - AC4: 'Reply on SC2', Claudio Luchinat, 29 Dec 2020
RC2: 'A very interesting investigation on the effect of cross-relaxation on paramagnetic relaxation enhancements', Fabien Ferrage, 24 Dec 2020
- AC3: 'Reply on RC2', Claudio Luchinat, 29 Dec 2020
RC3: 'Interactive comment on "Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?"', Carol Post, 05 Jan 2021
- AC5: 'Reply on RC3', Claudio Luchinat, 05 Jan 2021

Peer-review completion

AR: Author's response | RR: Referee report | ED: Editor decision

AR by Claudio Luchinat on behalf of the Authors (08 Jan 2021) Author's response Manuscript

ED: Publish as is (11 Jan 2021) by Rolf Boelens

Post-review adjustments

AA: Author's adjustment | EA: Editor approval

AA by Claudio Luchinat on behalf of the Authors (26 Jan 2021) Author's adjustment Manuscript

EA: Adjustments approved (27 Jan 2021) by Rolf Boelens

Short summary

The efficiency of MRI contrast agents can increase by exploiting magnetization transfer effects occurring in slow-rotating nanoparticles containing a paramagnetic metal ion and a large number of exchangeable surface protons, which can increase the water proton relaxation rate. Occurrence of magnetization transfer should also be considered to determine accurate metal–proton distances from the experimental proton relaxation rates for protons farther than 15 Å from the paramagnetic metal.