Articles | Volume 2, issue 1
Research article
29 Jan 2021
Research article |  | 29 Jan 2021

Revisiting paramagnetic relaxation enhancements in slowly rotating systems: how long is the long range?

Giovanni Bellomo, Enrico Ravera, Vito Calderone, Mauro Botta, Marco Fragai, Giacomo Parigi, and Claudio Luchinat

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Field: Liquid-state NMR | Topic: Theory
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Cited articles

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Aime, S., Botta, M., Esteban-Gómez, D., and Platas-Iglesias, C.: Characterisation of magnetic resonance imaging (MRI) contrast agents using NMR relaxometry, Mol. Phys., 117, 898–909,, 2019. 
Anelli, P. L., Bertini, I., Fragai, M., Lattuada, L., Luchinat, C., and Parigi, G.: Sulfonamide-Functionalized Gadolinium DTPA Complexes as Possible Contrast Agents for MRI: A Relaxometric Investigation, Eur. J. Inorg. Chem., 2000, 625–630,<625::AID-EJIC625>3.0.CO;2-2, 2000. 
Balayssac, S., Bertini, I., Bhaumik, A., Lelli, M., and Luchinat, C.: Paramagnetic shifts in solid-state NMR of proteins to elicit strucutral information, Proc. Natl. Acad. Sci. USA, 105, 17284–17289, 2008. 
Banci, L. and Luchinat, C.: Selective versus non-selective T1 experiments to determine metal-nucleus distances in paramagnetic proteins, Inorg. Chim. Acta, 275–276, 373–379, 1998. 
Short summary
The efficiency of MRI contrast agents can increase by exploiting magnetization transfer effects occurring in slow-rotating nanoparticles containing a paramagnetic metal ion and a large number of exchangeable surface protons, which can increase the water proton relaxation rate. Occurrence of magnetization transfer should also be considered to determine accurate metal–proton distances from the experimental proton relaxation rates for protons farther than 15 Å from the paramagnetic metal.