Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics
György Pintér,Katharina F. Hohmann,J. Tassilo Grün,Julia Wirmer-Bartoschek,Clemens Glaubitz,Boris Fürtig,and Harald Schwalbe
György Pintér
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Katharina F. Hohmann
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
J. Tassilo Grün
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Julia Wirmer-Bartoschek
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Clemens Glaubitz
Institute for Biophysical Chemistry, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Institute for Organic Chemistry and Chemical Biology, Center for
Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang
Goethe-Universität Frankfurt, Frankfurt 60438, Germany
Viewed
Total article views: 3,325 (including HTML, PDF, and XML)
HTML
PDF
XML
Total
BibTeX
EndNote
2,052
1,212
61
3,325
54
45
HTML: 2,052
PDF: 1,212
XML: 61
Total: 3,325
BibTeX: 54
EndNote: 45
Views and downloads (calculated since 10 Feb 2021)
Cumulative views and downloads
(calculated since 10 Feb 2021)
Total article views: 2,357 (including HTML, PDF, and XML)
HTML
PDF
XML
Total
BibTeX
EndNote
1,604
706
47
2,357
47
41
HTML: 1,604
PDF: 706
XML: 47
Total: 2,357
BibTeX: 47
EndNote: 41
Views and downloads (calculated since 11 May 2021)
Cumulative views and downloads
(calculated since 11 May 2021)
Total article views: 968 (including HTML, PDF, and XML)
HTML
PDF
XML
Total
BibTeX
EndNote
448
506
14
968
7
4
HTML: 448
PDF: 506
XML: 14
Total: 968
BibTeX: 7
EndNote: 4
Views and downloads (calculated since 10 Feb 2021)
Cumulative views and downloads
(calculated since 10 Feb 2021)
Viewed (geographical distribution)
Total article views: 3,325 (including HTML, PDF, and XML)
Thereof 2,940 with geography defined
and 385 with unknown origin.
Total article views: 2,357 (including HTML, PDF, and XML)
Thereof 2,152 with geography defined
and 205 with unknown origin.
Total article views: 968 (including HTML, PDF, and XML)
Thereof 788 with geography defined
and 180 with unknown origin.
The folding, refolding and misfolding of biomacromolecules including proteins, DNA and RNA is an important area of biophysical research to understand functional and disease states of a cell. NMR spectroscopy provides detailed insight, with both high time and atomic resolution. These experiments put stringent requirements on signal-to-noise for often irreversible folding reactions. The review describes methodological approaches and highlights key applications.
The folding, refolding and misfolding of biomacromolecules including proteins, DNA and RNA is an...