Articles | Volume 2, issue 1
https://doi.org/10.5194/mr-2-291-2021
https://doi.org/10.5194/mr-2-291-2021
Review article
 | 
11 May 2021
Review article |  | 11 May 2021

Real-time nuclear magnetic resonance spectroscopy in the study of biomolecular kinetics and dynamics

György Pintér, Katharina F. Hohmann, J. Tassilo Grün, Julia Wirmer-Bartoschek, Clemens Glaubitz, Boris Fürtig, and Harald Schwalbe

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Latest update: 17 May 2024
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Short summary
The folding, refolding and misfolding of biomacromolecules including proteins, DNA and RNA is an important area of biophysical research to understand functional and disease states of a cell. NMR spectroscopy provides detailed insight, with both high time and atomic resolution. These experiments put stringent requirements on signal-to-noise for often irreversible folding reactions. The review describes methodological approaches and highlights key applications.