Articles | Volume 2, issue 1
Research article
19 May 2021
Research article |  | 19 May 2021

Determination of hydrogen exchange and relaxation parameters in PHIP complexes at micromolar concentrations

Lisanne Sellies, Ruud L. E. G. Aspers, and Marco Tessari


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-23', Malcolm Levitt, 09 Apr 2021
    • AC1: 'Reply on RC1', Marco Tessari, 29 Apr 2021
  • RC2: 'Comment on mr-2021-23', Eduard Chekmenev, 15 Apr 2021
    • AC2: 'Reply on RC2', Marco Tessari, 29 Apr 2021
  • RC3: 'Comment on mr-2021-23', Vladimir Zhivonitko, 16 Apr 2021
    • AC3: 'Reply on RC3', Marco Tessari, 29 Apr 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Marco Tessari on behalf of the Authors (29 Apr 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to corrections (30 Apr 2021) by Rolf Boelens
Short summary
Reversible para-hydrogen-induced polarization (PHIP) is a technique to enhance NMR signals in solution, based on the association/dissociation of para-hydrogen and substrate molecules with/from an iridium catalyst. In this work we present an approach to measure NMR relaxation as well as rate constants of para-hydrogen association/dissociation with/from the iridium catalyst. These rates are important for understanding the different PHIP efficiencies observed for different substrate molecules.