Articles | Volume 2, issue 1
Research article
01 Jul 2021
Research article |  | 01 Jul 2021

Exclusively heteronuclear NMR experiments for the investigation of intrinsically disordered proteins: focusing on proline residues

Isabella C. Felli, Wolfgang Bermel, and Roberta Pierattelli


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-37', Anonymous Referee #1, 26 Apr 2021
  • RC2: 'Comment on mr-2021-37', Anonymous Referee #2, 30 Apr 2021
  • AC1: 'Comment on mr-2021-37', Isabella Felli, 19 May 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Isabella Felli on behalf of the Authors (20 May 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to corrections (02 Jun 2021) by Fabien Ferrage
AR by Isabella Felli on behalf of the Authors (11 Jun 2021)  Author's response    Manuscript
Short summary
NMR represents a key spectroscopic technique for studying intrinsically disordered proteins (IDPs) that lack a stable three-dimensional structure. We present a set of NMR experiments tailored for proline residues, which are highly abundant in IDPs. The novel experiments have very interesting properties for the investigation of IDPs of increasing complexity.