Articles | Volume 2, issue 2
https://doi.org/10.5194/mr-2-835-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Special issue:
https://doi.org/10.5194/mr-2-835-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Selective excitation enables encoding and measurement of multiple diffusion parameters in a single experiment
Neil MacKinnon
CORRESPONDING AUTHOR
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Mehrdad Alinaghian
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Pedro Silva
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
DeepSpin GmbH, Kurfürstenstraße 56, 10785 Berlin, Germany
Thomas Gloge
Institute of Biological Interfaces (IBG-4), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Burkhard Luy
Institute of Biological Interfaces (IBG-4), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Mazin Jouda
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany
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Mengjia He, Neil MacKinnon, Dominique Buyens, Burkhard Luy, and Jan G. Korvink
Magn. Reson., 6, 173–181, https://doi.org/10.5194/mr-6-173-2025, https://doi.org/10.5194/mr-6-173-2025, 2025
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Parallel NMR (nuclear magnetic resonance) detection enhances measurement throughput for high-throughput screening. However, local gradients in parallel detectors cause field spillover in adjacent channels, leading to spin dephasing and signal loss. This study introduces a compensation scheme using optimized pulses to mitigate gradient-induced field inhomogeneity through coherence locking. The proposed approach offers an effective solution for NMR probes with parallel, independently switchable gradient coils.
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Magn. Reson. Discuss., https://doi.org/10.5194/mr-2025-10, https://doi.org/10.5194/mr-2025-10, 2025
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High critical field superconductors are less sensitive to magnet quenching, providing even higher fields. They can be cooled using cryogens like Helium, but simply using an oscillating pressure field. Using solar or wind energy, the cheap cooling promises magnetic resonance at high field, low operating cost, and renewable energy. Such magnets, made compact, can be used to prepolarise chemical samples, to be analysed in benchtop NMR systems, with better nuclear magnetic resonance spectra.
Sagar Wadhwa, Nan Wang, Klaus-Martin Reichert, Manuel Butzer, Omar Nassar, Mazin Jouda, Jan G. Korvink, Ulrich Gengenbach, Dario Mager, and Martin Ungerer
Magn. Reson., 6, 199–210, https://doi.org/10.5194/mr-6-199-2025, https://doi.org/10.5194/mr-6-199-2025, 2025
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We present a technology that allows for the direct writing of conductive tracks on cylindrical substrates as receiver coils for magnetic resonance (MR) experiments. The structures are written with high precision, which has two benefits. First, the real structures behave very similarly to the simulated designs, reducing the component variation; second, this allows for the writing of coils apart from the fairly straightforward solenoidal coils, thereby making complex designs available for MR microcoils.
Mengjia He, Neil MacKinnon, Dominique Buyens, Burkhard Luy, and Jan G. Korvink
Magn. Reson., 6, 173–181, https://doi.org/10.5194/mr-6-173-2025, https://doi.org/10.5194/mr-6-173-2025, 2025
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Parallel NMR (nuclear magnetic resonance) detection enhances measurement throughput for high-throughput screening. However, local gradients in parallel detectors cause field spillover in adjacent channels, leading to spin dephasing and signal loss. This study introduces a compensation scheme using optimized pulses to mitigate gradient-induced field inhomogeneity through coherence locking. The proposed approach offers an effective solution for NMR probes with parallel, independently switchable gradient coils.
Jan Korvink
Magn. Reson. Discuss., https://doi.org/10.5194/mr-2022-24, https://doi.org/10.5194/mr-2022-24, 2023
Publication in MR not foreseen
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The magic angle spinning (MAS) technique of solid state NMR requires samples to be rapidly rotated within a magnetic field. The rotation rate speed record is 150 kHz, or 9 million RPM, and hence MAS turbines hold the world rotation speed record for extended objects. The containers holding the samples are made of the strongest materials known, to be able to withstand the excessive centrifugal forces. To overcome the speed limit, this paper delineates a way to do so using an optical tweezers setup
Jens D. Haller, David L. Goodwin, and Burkhard Luy
Magn. Reson., 3, 53–63, https://doi.org/10.5194/mr-3-53-2022, https://doi.org/10.5194/mr-3-53-2022, 2022
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In contrast to adiabatic excitation, recently introduced SORDOR-90 pulses provide effective transverse 90° rotations throughout their bandwidth, with a quadratic offset dependence of the phase in the x,y plane. Together with phase-matched SORDOR-180 pulses, this enables a direct implementation of the Böhlen–Bodenhausen approach for frequency-swept pulses for a type of 90°/180° pulse–delay sequence. Example pulse shapes are characterised, and an application is given with a 19F-PROJECT experiment.
Cyril Charlier, Neil Cox, Sophie Martine Prud'homme, Alain Geffard, Jean-Marc Nuzillard, Burkhard Luy, and Guy Lippens
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Magn. Reson., 2, 607–617, https://doi.org/10.5194/mr-2-607-2021, https://doi.org/10.5194/mr-2-607-2021, 2021
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We use the theory of magnetostatic reciprocity to compute manufacturable solutions of complex magnet geometries, establishing a quantitative metric for the placement and subsequent orientation of discrete pieces of permanent magnetic material. This leads to self-assembled micro-magnets, adjustable magnetic arrays, and an unbounded magnetic field intensity in a small volume, despite realistic modelling of complex material behaviours.
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Magnetic resonance detectors require a high degree of precision to be useful. Their design must e.g. carefully weigh field strength and field homogeneity to find the best compromise. Here we show that inverse computational design is a viable method to find such a
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We have assembled a few off-the-shelf electronic chips and a popular Arduino Uno microcomputer board in an automatic system that performs so-called tuning and matching of an arbitrary NMR probe head at very low cost. This removes the tedium of doing the job by hand, the bane of many NMR analysts. It also brings accuracy and repeatability into the process, which is so necessary for high throughput analysis or when working with low-field permanent magnesystems with excessive magnetic field drift.
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Field: Liquid-state NMR | Topic: Applications – small molecules
1H-enhanced 103Rh NMR spectroscopy and relaxometry of 103Rh(acac)3 in solution
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Harry Harbor-Collins, Mohamed Sabba, Markus Leutzsch, and Malcolm H. Levitt
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The nuclear magnetic resonance (NMR) spectroscopy of the 103Rh nucleus is onerous owing to its dismal sensitivity. Here, we utilise modern techniques to boost the sensitivity and acquire valuable 103Rh NMR parameters for the Rh(acac)3 transition-metal complex. We acquire proton-enhanced 103Rh NMR spectra and successfully characterise the 103Rh spin relaxation. In doing so, we unveil the secrets of a complex that is of significant interest to the 103Rh NMR and wider chemical community alike.
Jamie Guest, Peter Kiraly, Mathias Nilsson, and Gareth A. Morris
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The application of anisotropic NMR parameters for the correct structural assignment of small molecules requires the use of partially ordered media. Previously, we demonstrated that P3D simulations allow for the determination of the correct diastereomer. Here we show that when steric or electrostatic factors dominate the alignment, P3D retains its diastereomer discrimination power and can define conformational ensembles of flexible molecules from sparse NMR data.
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Short summary
To increase experimental efficiency, information can be encoded in parallel by taking advantage of highly resolved NMR spectra. Here we demonstrate parallel encoding of optimal diffusion parameters by selectively using a resonance for each molecule in the sample. This yields a factor of n decrease in experimental time since n experiments can be encoded into a single measurement. This principle can be extended to additional experimental parameters as a means to further improve measurement time.
To increase experimental efficiency, information can be encoded in parallel by taking advantage...
Special issue