Articles | Volume 2, issue 2
Research article
25 Nov 2021
Research article |  | 25 Nov 2021

NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR

Yulia Pustovalova, Frank Delaglio, D. Levi Craft, Haribabu Arthanari, Ad Bax, Martin Billeter, Mark J. Bostock, Hesam Dashti, D. Flemming Hansen, Sven G. Hyberts, Bruce A. Johnson, Krzysztof Kazimierczuk, Hengfa Lu, Mark Maciejewski, Tomas M. Miljenović, Mehdi Mobli, Daniel Nietlispach, Vladislav Orekhov, Robert Powers, Xiaobo Qu, Scott Anthony Robson, David Rovnyak, Gerhard Wagner, Jinfa Ying, Matthew Zambrello, Jeffrey C. Hoch, David L. Donoho, and Adam D. Schuyler

Related authors

Facilitating the structural characterisation of non-canonical amino acids in biomolecular NMR
Sarah Kuschert, Martin Stroet, Yanni Ka-Yan Chin, Anne Claire Conibear, Xinying Jia, Thomas Lee, Christian Reinhard Otto Bartling, Kristian Strømgaard, Peter Güntert, Karl Johan Rosengren, Alan Edward Mark, and Mehdi Mobli
Magn. Reson., 4, 57–72,,, 2023
Short summary
Anomalous amide proton chemical shifts as signatures of hydrogen bonding to aromatic sidechains
Kumaran Baskaran, Colin W. Wilburn, Jonathan R. Wedell, Leonardus M. I. Koharudin, Eldon L. Ulrich, Adam D. Schuyler, Hamid R. Eghbalnia, Angela M. Gronenborn, and Jeffrey C. Hoch
Magn. Reson., 2, 765–775,,, 2021
Short summary
Four-dimensional NOE-NOE spectroscopy of SARS-CoV-2 Main Protease to facilitate resonance assignment and structural analysis
Angus J. Robertson, Jinfa Ying, and Ad Bax
Magn. Reson., 2, 129–138,,, 2021
Short summary

Related subject area

Field: Liquid-state NMR | Topic: Signal processing methods
Application of multiplet structure deconvolution to extract scalar coupling constants from 1D nuclear magnetic resonance spectra
Damien Jeannerat and Carlos Cobas
Magn. Reson., 2, 545–555,,, 2021
Short summary

Cited articles

Amstutz, P., Crusoe, M. R., Tijanić, N., Chapman, B., Chilton, J., Heuer, M., Kartashov, A., Kern, J., Leehr, D., Ménager, H., Nedeljkovich, M., Scales, M., Soiland-Reyes, S., and Stojanovic, L.: Common Workflow Language, v1.0, figshare [data set],, 2016. a
Barna, J. C. and Laue, E. D.: Conventional and exponential sampling for 2D NMR experiments with application to a 2D NMR spectrum of a protein, J. Magn. Reson., 75, 384–389,, 1987. a
Billeter, M. and Orekhov, V.: Novel sampling approaches in higher dimensional NMR, vol. 316, Springer Science & Business Media, Heidelberg,, 2012. a
Bodenhausen, G. and Ernst, R.: The accordion experiment, a simple approach to three-dimensional NMR spectroscopy, J. Magn. Reson., 45, 367–373, 1981. a
Bostock, M. and Nietlispach, D.: Compressed sensing: Reconstruction of non-uniformly sampled multidimensional NMR data, Concepts Magn. Reson. A, 46, e21438,, 2017. a, b
Short summary
We present the ongoing work of a large, community initiative to establish standards for the processing of nonuniformly sampled NMR experiments. The NUScon software, contest, and archive of spectral evaluation data provide a comprehensive platform for addressing the most challenging questions related to NUS experiments. We will run annual contests and generate a database of results, which will empower us in guiding the NUS community towards a set of best practices.