Magnetic Resonance
Magnetic Resonance
MR
Articles | Volume 6, issue 2
Articles | Volume 6, issue 2
https://doi.org/10.5194/mr-6-131-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-6-131-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 6, issue 2
Research article
 | 
14 Jul 2025
Research article |  | 14 Jul 2025

Inter-residue through-space scalar 19F–19F couplings between CH2F groups in a protein

Yi Jiun Tan, Elwy H. Abdelkader, Iresha D. Herath, Ansis Maleckis, and Gottfried Otting

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Short summary
A protein is produced where a single amino acid type is substituted globally by a fluorinated analogue. Through-space fluorine–fluorine contacts are observed by 19F NMR (nuclear magnetic resonance) spectroscopy. Substitution of methyl groups by CH2F groups yields outstanding spectral resolution with minimal structural perturbation of the protein. Our work identifies the γ-gauche effect as the main reason for the spectral dispersion.
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