Articles | Volume 6, issue 2
https://doi.org/10.5194/mr-6-229-2025
https://doi.org/10.5194/mr-6-229-2025
Research article
 | 
03 Sep 2025
Research article |  | 03 Sep 2025

A fast sample shuttle to couple high and low magnetic fields and applications in high-resolution relaxometry

Jorge A. Villanueva-Garibay, Andreas Tilch, Ana Paula Aguilar Alva, Guillaume Bouvignies, Frank Engelke, Fabien Ferrage, Agnes Glémot, Ulric B. le Paige, Giulia Licciardi, Claudio Luchinat, Giacomo Parigi, Philippe Pelupessy, Enrico Ravera, Alessandro Ruda, Lucas Siemons, Olof Stenström, and Jean-Max Tyburn

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Cited articles

Aders, P., Tilch, A., Marquardsen, T., and Tyburn, J.-M.: Pneumatic cable shuttle system for 2FNMR, US patent, US 11 474 172 B1, 2022. Barskiy, D. A., Blanchard, J. W., Budker, D., Eills, J., Pustelny, S., Sheberstov, K. F., Tayler, M. C. D., and Trabesinger, A.: Zero- to Ultralow-field Nuclear Magnetic Resonance, Prog. Nucl. Mag. Res. Sp., 148–149, 101558, https://doi.org/10.1016/j.pnmrs.2025.101558, 2025. 
Carravetta, M., Johannessen, O. G., and Levitt, M. H.: Beyond the T1 Limit: Singlet Nuclear Spin States in Low Magnetic Fields, Phys. Rev. Lett., 92, 153003, https://doi.org/10.1103/PhysRevLett.92.153003, 2004. 
Charlier, C., Khan, S. N., Marquardsen, T., Pelupessy, P., Reiss, V., Sakellariou, D., Bodenhausen, G., Engelke, F., and Ferrage, F.: Nanosecond Time Scale Motions in Proteins Revealed by High-Resolution NMR Relaxometry, J. Am. Chem. Soc., 135, 18665–18672, https://doi.org/10.1021/ja409820g, 2013. 
Chou, C. Y., Chu, M. L., Chang, C. F., and Huang, T. H.: A compact high-speed mechanical sample shuttle for field-dependent high-resolution solution NMR, J. Magn. Reson., 214, 302–308, https://doi.org/10.1016/j.jmr.2011.12.001, 2012. 
Chou, C.-Y., Chu, M., Chang, C.-F., Yu, T., Huang, T., and Sakellariou, D.: High sensitivity high-resolution full range relaxometry using a fast mechanical sample shuttling device and a cryo-probe, J. Biomol. NMR, 66, 187–194, https://doi.org/10.1007/s10858-016-0066-5, 2016. 
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Short summary
Investigating NMR (nuclear magnetic resonance) phenomena at variable magnetic fields is useful and insightful for hyperpolarization and molecular dynamics in particular. To benefit from high-resolution at high magnetic fields, field-dependent investigations can be performed using a high-field NMR spectrometer, with a sample shuttle apparatus for field cycling. Here, we introduce a new design of a sample shuttle which is fast, reliable, and narrow. We show a series of applications involving small molecules and a protein in solution.
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