Bootstrap aggregation for model selection in the model-free formalism

Crawley, Timothy; Palmer III, Arthur G.

doi:https://doi.org/10.5194/mr-2-251-2021

Articles | Volume 2, issue 1

https://doi.org/10.5194/mr-2-251-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Special issue:

Geoffrey Bodenhausen Festschrift

https://doi.org/10.5194/mr-2-251-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 2, issue 1

Research article

|

05 May 2021

Research article |

| 05 May 2021

Bootstrap aggregation for model selection in the model-free formalism

Timothy Crawley and Arthur G. Palmer III

Supplement

https://doi.org/10.5194/mr-2-251-2021-supplement

Data sets

Data for: Dynamics of GCN4 facilitate DNA interaction: a model-free analysis of an intrinsically disordered region Michelle L. Gill, R. Andrew Byrd, and Arthur G. Palmer https://doi.org/10.17632/vpwz6mrynr.1

Short summary

NMR relaxation rate constants are powerful probes of the functional dynamics of biological macromolecules, such as proteins and nucleic acids. However, variations in choice of models used to analyze relaxation data obscure variations due to critical biological or chemical effects. Bootstrap aggregation, a recently developed statistical method, circumvents the model selection problem and enables more consistent and insightful interpretation of NMR relaxation data.