Articles | Volume 2, issue 1
Research article
05 May 2021
Research article |  | 05 May 2021

Bootstrap aggregation for model selection in the model-free formalism

Timothy Crawley and Arthur G. Palmer III


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-28', Anonymous Referee #1, 28 Mar 2021
  • RC2: 'Comment on mr-2021-28', Anonymous Referee #2, 02 Apr 2021
  • RC3: 'Comment on mr-2021-28', Anonymous Referee #3, 05 Apr 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Arthur Palmer on behalf of the Authors (16 Apr 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to minor revisions (review by editor) (19 Apr 2021) by Malcolm Levitt
ED: Publish as is (21 Apr 2021) by Malcolm Levitt
Short summary
NMR relaxation rate constants are powerful probes of the functional dynamics of biological macromolecules, such as proteins and nucleic acids. However, variations in choice of models used to analyze relaxation data obscure variations due to critical biological or chemical effects. Bootstrap aggregation, a recently developed statistical method, circumvents the model selection problem and enables more consistent and insightful interpretation of NMR relaxation data.