Articles | Volume 2, issue 1
Research article
07 May 2021
Research article |  | 07 May 2021

Non-classical disproportionation revealed by photo-chemically induced dynamic nuclear polarization NMR

Jakob Wörner, Jing Chen, Adelbert Bacher, and Stefan Weber


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-22', Anonymous Referee #1, 03 Mar 2021
  • RC2: 'Comment on mr-2021-22', Anonymous Referee #2, 25 Mar 2021
  • AC1: 'Author Comment on mr-2021-22', Stefan Weber, 31 Mar 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Stefan Weber on behalf of the Authors (03 Apr 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish as is (07 Apr 2021) by Rolf Boelens
Short summary
Methyl groups are rarely acidic. But in a lumazine derivative with biological significance the position-7 methyl group can be deprotonated. The existence of two protonation states is a prerequisite for a non-classical disproportionation reaction initiated by light. We provide evidence for such dismutation using a variant of nuclear magnetic resonance that is capable of detecting nuclear hyperpolarization. Our findings may shed new light on enzymatic riboflavin biosynthesis.