Magnetic Resonance
Magnetic Resonance
MR
Articles | Volume 2, issue 2
Articles | Volume 2, issue 2
https://doi.org/10.5194/mr-2-557-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Special issue:
https://doi.org/10.5194/mr-2-557-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 2, issue 2
Research article
 | 
06 Jul 2021
Research article |  | 06 Jul 2021

Detecting anisotropic segmental dynamics in disordered proteins by cross-correlated spin relaxation

Clemens Kauffmann, Irene Ceccolini, Georg Kontaxis, and Robert Konrat

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Latest update: 12 Nov 2024
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Short summary
Unlike rigid folded proteins, intrinsically disordered proteins (IDPs) exist as an ensemble of dynamically interconverting structures. Cross-correlated spin-relaxation experiments are particularly suited to characterize the structural dynamics of IDPs as they encode a protein's structural memory. By translating diffusion models of folded proteins to segmental motions in IDPs, we define and assess a sensitive experimental measure for the presence of anisotropic dynamics in the protein backbone.
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