Articles | Volume 2, issue 2
https://doi.org/10.5194/mr-2-557-2021
https://doi.org/10.5194/mr-2-557-2021
Research article
 | 
06 Jul 2021
Research article |  | 06 Jul 2021

Detecting anisotropic segmental dynamics in disordered proteins by cross-correlated spin relaxation

Clemens Kauffmann, Irene Ceccolini, Georg Kontaxis, and Robert Konrat

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Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-35', Anonymous Referee #1, 17 Apr 2021
  • RC2: 'Please see attached file.', Anonymous Referee #2, 22 Apr 2021
  • RC3: 'Comment on mr-2021-35', Anonymous Referee #2, 01 May 2021
    • AC3: 'Reply on RC3', Clemens Kauffmann, 05 May 2021
      • AC4: 'Reply on AC3', Clemens Kauffmann, 06 May 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision | EF: Editorial file upload
AR by Clemens Kauffmann on behalf of the Authors (25 May 2021)  Author's response   Author's tracked changes   Manuscript 
ED: Publish as is (02 Jun 2021) by Daniel Abergel
AR by Clemens Kauffmann on behalf of the Authors (02 Jun 2021)  Manuscript 
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Short summary
Unlike rigid folded proteins, intrinsically disordered proteins (IDPs) exist as an ensemble of dynamically interconverting structures. Cross-correlated spin-relaxation experiments are particularly suited to characterize the structural dynamics of IDPs as they encode a protein's structural memory. By translating diffusion models of folded proteins to segmental motions in IDPs, we define and assess a sensitive experimental measure for the presence of anisotropic dynamics in the protein backbone.