Articles | Volume 2, issue 2
Research article
10 Aug 2021
Research article |  | 10 Aug 2021

Virtual decoupling to break the simplification versus resolution trade-off in nuclear magnetic resonance of complex metabolic mixtures

Cyril Charlier, Neil Cox, Sophie Martine Prud'homme, Alain Geffard, Jean-Marc Nuzillard, Burkhard Luy, and Guy Lippens


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-48', Anonymous Referee #1, 22 Jun 2021
  • RC2: 'Comment on mr-2021-48', Oscar Millet, 24 Jun 2021
  • RC3: 'Comment on mr-2021-48', Anonymous Referee #3, 12 Jul 2021
  • AC1: 'Comment on mr-2021-48', Cyril Charlier, 16 Jul 2021
  • AC2: 'Comment on mr-2021-48', Cyril Charlier, 21 Jul 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Cyril Charlier on behalf of the Authors (16 Jul 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to corrections (19 Jul 2021) by Fabien Ferrage
Short summary
The HSQC experiment developed by Bodenhausen and Ruben is a cornerstone for modern NMR. When used in the field of metabolomics, the common practice of decoupling in the proton dimension limits the acquisition time and hence the resolution. Here, we present a virtual decoupling method to maintain both spectral simplicity and resolution, and demonstrate how it increases information content with the zebra mussel metabolome as an example.