Magnetic Resonance
Magnetic Resonance
MR
Articles | Volume 2, issue 2
Articles | Volume 2, issue 2
https://doi.org/10.5194/mr-2-777-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-2-777-2021
© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 2, issue 2
Research article
 | 
03 Nov 2021
Research article |  | 03 Nov 2021

Analysis of conformational exchange processes using methyl-TROSY-based Hahn echo measurements of quadruple-quantum relaxation

Christopher A. Waudby and John Christodoulou

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Latest update: 13 Dec 2024
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Short summary
We describe a suite of experiments that exploit field-dependent relaxation measurements of four-spin transitions in methyl groups to characterise chemical exchange processes and which can be used as an alternative or complement to CPMG relaxation dispersion measurements. We show that these four-spin transitions benefit from the methyl TROSY effect and so provide a unique combination of slow intrinsic relaxation and high sensitivity to chemical exchange.
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