Articles | Volume 2, issue 2
Magn. Reson., 2, 815–825, 2021
https://doi.org/10.5194/mr-2-815-2021

Special issue: Geoffrey Bodenhausen Festschrift

Magn. Reson., 2, 815–825, 2021
https://doi.org/10.5194/mr-2-815-2021

Research article 11 Nov 2021

Research article | 11 Nov 2021

A cryogen-free, semi-automated apparatus for bullet-dynamic nuclear polarization with improved resolution

Karel Kouřil et al.

Related subject area

Field: Hyperpolarization | Topic: Instrumentation
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Magn. Reson., 2, 387–394, https://doi.org/10.5194/mr-2-387-2021,https://doi.org/10.5194/mr-2-387-2021, 2021
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Increased flow rate of hyperpolarized aqueous solution for dynamic nuclear polarization-enhanced magnetic resonance imaging achieved by an open Fabry–Pérot type microwave resonator
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Magn. Reson., 1, 275–284, https://doi.org/10.5194/mr-1-275-2020,https://doi.org/10.5194/mr-1-275-2020, 2020
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Cited articles

Ardenkjær-Larsen, J. H.: On the Present and Future of Dissolution-DNP, J. Magn. Reson., 264, 3–12, https://doi.org/10.1016/j.jmr.2016.01.015, 2016. a
Ardenkjær-Larsen, J. H.: Introduction to dissolution DNP: Overview, instrumentation, and human applications, Handbook of High Field Dynamic Nuclear Polarization, John Wiley & Sons, Chichester, UK, p. 239, 2019. a
Ardenkjær-Larsen, J. H., Fridlund, B., Gram, A., Hansson, G., Hansson, L., Lerche, M. H., Servin, R., Thaning, M., and Golman, K.: Increase in Signal-To-Noise Ratio of > 10 000 Times in Liquid-State NMR, P. Natl. Acad. Sci. USA, 100, 10158–10163, https://doi.org/10.1073/pnas.1733835100, 2003. a
Ardenkjaer-Larsen, J.-H., Boebinger, G. S., Comment, A., Duckett, S., Edison, A. S., Engelke, F., Griesinger, C., Griffin, R. G., Hilty, C., Maeda, H., Parigi, G., Prisner, T., Ravera, E., van Bentum, J., Vega, S., Webb, A., Luchinat, C., Schwalbe, H., and Frydman, L.: Facing and Overcoming Sensitivity Challenges in Biomolecular NMR Spectroscopy, Angew. Chem. Int. Edit., 54, 9162–9185, https://doi.org/10.1002/anie.201410653, 2015. a
Ardenkjær-Larsen, J. H., Bowen, S., Petersen, J. R., Rybalko, O., Vinding, M. S., Ullisch, M., and Nielsen, N. C.: Cryogen-Free Dissolution Dynamic Nuclear Polarization Polarizer Operating At 3.35 T, 6.70 T, and 10.1 T, Magn. Reson. Med., 81, 2184, https://doi.org/10.1002/mrm.27537, 2018. a
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Short summary
The signals that are attainable in conventional NMR are tiny, and consequentially, NMR is often slow and insensitive. The intensity may be increased by hyperpolarization, provided that the spectral quality is essentially preserved. We have recently reported a potentially powerful hyperpolarization scheme, named bullet-DNP (dynamic nuclear polarization). Here, we report a 10-fold improvement in resolution for that method, which may enable new applications in metabolomics and drug discovery.