Magnetic Resonance
Magnetic Resonance
Magnetic Resonance
Articles | Volume 3, issue 1
Articles | Volume 3, issue 1
Magn. Reson., 3, 91–99, 2022
https://doi.org/10.5194/mr-3-91-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
Magn. Reson., 3, 91–99, 2022
https://doi.org/10.5194/mr-3-91-2022
© Author(s) 2022. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 3, issue 1
Research article
20 May 2022
Research article | 20 May 2022

Imatinib disassembles the regulatory core of Abelson kinase by binding to its ATP site and not by binding to its myristoyl pocket

Stephan Grzesiek et al.

Viewed

Total article views: 1,497 (including HTML, PDF, and XML)
HTML PDF XML Total Supplement BibTeX EndNote
1,210 256 31 1,497 19 9 8
  • HTML: 1,210
  • PDF: 256
  • XML: 31
  • Total: 1,497
  • Supplement: 19
  • BibTeX: 9
  • EndNote: 8
Views and downloads (calculated since 28 Mar 2022)
Cumulative views and downloads (calculated since 28 Mar 2022)

Viewed (geographical distribution)

Total article views: 1,275 (including HTML, PDF, and XML) Thereof 1,275 with geography defined and 0 with unknown origin.
Country # Views %
  • 1
1
 
 
 
 
Latest update: 29 Jun 2022
Download
Short summary
We show here that binding of the anticancer drug imatinib to the ATP site of Abelson kinase and not binding to its allosteric site coincides with the opening of the kinase regulatory core at nanomolar concentrations. This has implications for the understanding of Abelson’s kinase regulation and activity during medication as well as for the design of new Abelson kinase inhibitors.
Read more