Articles | Volume 4, issue 1
Research article
15 Mar 2023
Research article |  | 15 Mar 2023

Multidimensional encoding of restricted and anisotropic diffusion by double rotation of the q vector

Hong Jiang, Leo Svenningsson, and Daniel Topgaard

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Cited articles

Aggarwal, M.: Restricted diffusion and spectral content of the gradient waveforms, in: Advanced Diffusion Encoding Methods in MRI, edited by: Topgaard, D., Royal Society of Chemistry, Cambridge, UK, 103–122,, 2020. 
Andrew, E. R., Bradbury, A., and Eades, R. G.: Removal of dipolar broadening of nuclear magnetic resonance spectra of solids by specimen rotation, Nature, 183, 1802–1803,, 1959. 
Arbabi, A., Kai, J., Khan, A. R., and Baron, C. A.: Diffusion dispersion imaging: Mapping oscillating gradient spin-echo frequency dependence in the human brain, Magn. Reson. Med., 83, 2197–2208,, 2020. 
Åslund, I. and Topgaard, D.: Determination of the self-diffusion coefficient of intracellular water using PGSE NMR with variable gradient pulse length, J. Magn. Reson., 201, 250–254,, 2009. 
Balinov, B., Jönsson, B., Linse, P., and Söderman, O.: The NMR self-diffusion method applied to restricted diffusion. Simulation of echo attenuation from molecules in spheres and between planes, J. Magn. Reson. A, 104, 17–25,, 1993. 
Short summary
Diffusion MRI is a clinically important tool for noninvasive detection of pathological conditions that lead to microscopic changes in cell and tissue structures, but this technique suffers from interpretational ambiguities when applied to heterogeneous and disordered tissues comprising cells with multiple sizes, shapes, and orientations. We propose a simple scheme to encode the MRI signal with a sufficient amount of information to resolve and study all properties simultaneously.