Magnetic Resonance
Magnetic Resonance
MR
Articles | Volume 5, issue 1
Articles | Volume 5, issue 1
https://doi.org/10.5194/mr-5-61-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-5-61-2024
© Author(s) 2024. This work is distributed under
the Creative Commons Attribution 4.0 License.
Articles | Volume 5, issue 1
Research article
 | 
15 May 2024
Research article |  | 15 May 2024

Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform

Wolf Wüster, Pit Gebbers, Alois Renn, Matthias Bütikofer, Sophie Rüdiger, Roland P. Riek, and Felix Torres

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Short summary
Drug discovery requires the testing of a large number of samples to identify molecules with a potential therapeutic potential. The recent development of methods to perform such tests within seconds using sample illumination in a magnetic field could increase the throughput of such studies. We present a setup that integrates light into fully automated and commercially available instrumentation. This platform upgrade can increase the drug discovery throughput by a factor of 20 to 50-fold.
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