Articles | Volume 5, issue 1
https://doi.org/10.5194/mr-5-61-2024
https://doi.org/10.5194/mr-5-61-2024
Research article
 | 
15 May 2024
Research article |  | 15 May 2024

Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform

Wolf Wüster, Pit Gebbers, Alois Renn, Matthias Bütikofer, Sophie Rüdiger, Roland P. Riek, and Felix Torres

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Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2024-3', Anonymous Referee #1, 04 Mar 2024
    • AC1: 'Reply on RC1', Felix Torres, 12 Mar 2024
  • RC2: 'Comment on mr-2024-3', Alexander P. Golovanov, 06 Mar 2024
    • AC2: 'Reply on RC2', Felix Torres, 12 Mar 2024
  • EC1: 'Comment on mr-2024-3', Daniella Goldfarb, 13 Mar 2024
    • AC3: 'Reply on EC1', Felix Torres, 15 Mar 2024

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision | EF: Editorial file upload
AR by Felix Torres on behalf of the Authors (15 Mar 2024)  Author's response   Author's tracked changes   Manuscript 
ED: Referee Nomination & Report Request started (19 Mar 2024) by Daniella Goldfarb
RR by Alexander P. Golovanov (27 Mar 2024)
ED: Publish as is (31 Mar 2024) by Daniella Goldfarb
AR by Felix Torres on behalf of the Authors (31 Mar 2024)  Manuscript 
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Short summary
Drug discovery requires the testing of a large number of samples to identify molecules with a potential therapeutic potential. The recent development of methods to perform such tests within seconds using sample illumination in a magnetic field could increase the throughput of such studies. We present a setup that integrates light into fully automated and commercially available instrumentation. This platform upgrade can increase the drug discovery throughput by a factor of 20 to 50-fold.