Articles | Volume 6, issue 2
https://doi.org/10.5194/mr-6-173-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
https://doi.org/10.5194/mr-6-173-2025
© Author(s) 2025. This work is distributed under
the Creative Commons Attribution 4.0 License.
the Creative Commons Attribution 4.0 License.
Coherence locking in a parallel nuclear magnetic resonance probe defends against gradient field spillover
Mengjia He
Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Neil MacKinnon
CORRESPONDING AUTHOR
Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Dominique Buyens
Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Burkhard Luy
Institute for Biological Interfaces 4 – Magnetic Resonance, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
Institute of Organic Chemistry, Karlsruhe Institute of Technology, Karlsruhe, Germany
Institute of Microstructure Technology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany
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Magn. Reson. Discuss., https://doi.org/10.5194/mr-2025-10, https://doi.org/10.5194/mr-2025-10, 2025
Preprint under review for MR
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High critical field superconductors are less sensitive to magnet quenching, providing even higher fields. They can be cooled using cryogens like Helium, but simply using an oscillating pressure field. Using solar or wind energy, the cheap cooling promises magnetic resonance at high field, low operating cost, and renewable energy. Such magnets, made compact, can be used to prepolarise chemical samples, to be analysed in benchtop NMR systems, with better nuclear magnetic resonance spectra.
Sagar Wadhwa, Nan Wang, Klaus-Martin Reichert, Manuel Butzer, Omar Nassar, Mazin Jouda, Jan G. Korvink, Ulrich Gengenbach, Dario Mager, and Martin Ungerer
Magn. Reson., 6, 199–210, https://doi.org/10.5194/mr-6-199-2025, https://doi.org/10.5194/mr-6-199-2025, 2025
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We present a technology that allows for the direct writing of conductive tracks on cylindrical substrates as receiver coils for magnetic resonance (MR) experiments. The structures are written with high precision, which has two benefits. First, the real structures behave very similarly to the simulated designs, reducing the component variation; second, this allows for the writing of coils apart from the fairly straightforward solenoidal coils, thereby making complex designs available for MR microcoils.
Jan Korvink
Magn. Reson. Discuss., https://doi.org/10.5194/mr-2022-24, https://doi.org/10.5194/mr-2022-24, 2023
Publication in MR not foreseen
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The magic angle spinning (MAS) technique of solid state NMR requires samples to be rapidly rotated within a magnetic field. The rotation rate speed record is 150 kHz, or 9 million RPM, and hence MAS turbines hold the world rotation speed record for extended objects. The containers holding the samples are made of the strongest materials known, to be able to withstand the excessive centrifugal forces. To overcome the speed limit, this paper delineates a way to do so using an optical tweezers setup
Jens D. Haller, David L. Goodwin, and Burkhard Luy
Magn. Reson., 3, 53–63, https://doi.org/10.5194/mr-3-53-2022, https://doi.org/10.5194/mr-3-53-2022, 2022
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In contrast to adiabatic excitation, recently introduced SORDOR-90 pulses provide effective transverse 90° rotations throughout their bandwidth, with a quadratic offset dependence of the phase in the x,y plane. Together with phase-matched SORDOR-180 pulses, this enables a direct implementation of the Böhlen–Bodenhausen approach for frequency-swept pulses for a type of 90°/180° pulse–delay sequence. Example pulse shapes are characterised, and an application is given with a 19F-PROJECT experiment.
Neil MacKinnon, Mehrdad Alinaghian, Pedro Silva, Thomas Gloge, Burkhard Luy, Mazin Jouda, and Jan G. Korvink
Magn. Reson., 2, 835–842, https://doi.org/10.5194/mr-2-835-2021, https://doi.org/10.5194/mr-2-835-2021, 2021
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To increase experimental efficiency, information can be encoded in parallel by taking advantage of highly resolved NMR spectra. Here we demonstrate parallel encoding of optimal diffusion parameters by selectively using a resonance for each molecule in the sample. This yields a factor of n decrease in experimental time since n experiments can be encoded into a single measurement. This principle can be extended to additional experimental parameters as a means to further improve measurement time.
Cyril Charlier, Neil Cox, Sophie Martine Prud'homme, Alain Geffard, Jean-Marc Nuzillard, Burkhard Luy, and Guy Lippens
Magn. Reson., 2, 619–627, https://doi.org/10.5194/mr-2-619-2021, https://doi.org/10.5194/mr-2-619-2021, 2021
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The HSQC experiment developed by Bodenhausen and Ruben is a cornerstone for modern NMR. When used in the field of metabolomics, the common practice of decoupling in the proton dimension limits the acquisition time and hence the resolution. Here, we present a virtual decoupling method to maintain both spectral simplicity and resolution, and demonstrate how it increases information content with the zebra mussel metabolome as an example.
Pedro Freire Silva, Mazin Jouda, and Jan G. Korvink
Magn. Reson., 2, 607–617, https://doi.org/10.5194/mr-2-607-2021, https://doi.org/10.5194/mr-2-607-2021, 2021
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We use the theory of magnetostatic reciprocity to compute manufacturable solutions of complex magnet geometries, establishing a quantitative metric for the placement and subsequent orientation of discrete pieces of permanent magnetic material. This leads to self-assembled micro-magnets, adjustable magnetic arrays, and an unbounded magnetic field intensity in a small volume, despite realistic modelling of complex material behaviours.
Sagar Wadhwa, Mazin Jouda, Yongbo Deng, Omar Nassar, Dario Mager, and Jan G. Korvink
Magn. Reson., 1, 225–236, https://doi.org/10.5194/mr-1-225-2020, https://doi.org/10.5194/mr-1-225-2020, 2020
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Magnetic resonance detectors require a high degree of precision to be useful. Their design must e.g. carefully weigh field strength and field homogeneity to find the best compromise. Here we show that inverse computational design is a viable method to find such a
trade-off. Apart from the electromagnetic field solution, the simulation program also determines the boundary between insulating and conducting material and moves the material boundaries around until the compromise is best satisfied.
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Short summary
Parallel NMR (nuclear magnetic resonance) detection enhances measurement throughput for high-throughput screening. However, local gradients in parallel detectors cause field spillover in adjacent channels, leading to spin dephasing and signal loss. This study introduces a compensation scheme using optimized pulses to mitigate gradient-induced field inhomogeneity through coherence locking. The proposed approach offers an effective solution for NMR probes with parallel, independently switchable gradient coils.
Parallel NMR (nuclear magnetic resonance) detection enhances measurement throughput for...