Articles | Volume 6, issue 2
https://doi.org/10.5194/mr-6-273-2025
https://doi.org/10.5194/mr-6-273-2025
Research article
 | 
24 Nov 2025
Research article |  | 24 Nov 2025

Long-lived states involving a manifold of fluorine-19 spins in fluorinated aliphatic chains

Coline Wiame, Sebastiaan Van Dyck, Kirill Sheberstov, Aiky Razanahoera, and Geoffrey Bodenhausen

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Revised manuscript not accepted

Cited articles

Aguilar, J. A., Nilsson, M., Bodenhausen, G., and Morris, G. A.: Spin echo NMR spectra without J modulation, Chem. Commun., 48, 811–813, https://doi.org/10.1039/C1CC16699A, 2012. 
Bornet, A., Ji, X., Mammoli, D., Vuichoud, B., Milani, J., Bodenhausen, G., and Jannin, S.: Long-Lived States of Magnetically Equivalent Spins Populated by Dissolution-DNP and Revealed by Enzymatic Reactions, Chem. – Eur. J., 20, 17113–17118, https://doi.org/10.1002/chem.201404967, 2014. 
Buchholz, C. R. and Pomerantz, W. C. K.: 19F NMR viewed through two different lenses: ligand-observed and protein-observed 19F NMR applications for fragment-based drug discovery, RSC Chem. Biol., 2, 1312–1330, https://doi.org/10.1039/D1CB00085C, 2021. 
Buratto, R., Mammoli, D., Canet, E., and Bodenhausen, G.: Ligand–Protein Affinity Studies Using Long-Lived States of Fluorine-19 Nuclei, J. Med. Chem., 59, 1960–1966, https://doi.org/10.1021/acs.jmedchem.5b01583, 2016. 
Cavadini, S., Dittmer, J., Antonijevic, S., and Bodenhausen, G.: Slow Diffusion by Singlet State NMR Spectroscopy, J. Am. Chem. Soc., 127, 15744–15748, https://doi.org/10.1021/ja052897b, 2005. 
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Short summary
In achiral polyfluoroalkyl substances with two to three CF₂ groups, long-lived ¹⁹F spin states (TLLS) were measured and found to last about three times longer than T₁ in a static 11.6 T field. These lifetimes are sensitive to macromolecular binding, making them useful for screening fluorinated drugs.
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