Articles | Volume 2, issue 1
Research article
11 Jun 2021
Research article |  | 11 Jun 2021

129Xe ultra-fast Z spectroscopy enables micromolar detection of biosensors on a 1 T benchtop spectrometer

Kévin Chighine, Estelle Léonce, Céline Boutin, Hervé Desvaux, and Patrick Berthault

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Cited articles

Ahola, S., Zhivonitko, V. V., Mankinen, O., Zhang, G., Kantola, A. M., Chen, H.-Y., Hilty, C., Koptyug, I. V., and Telkki, V.-V.: Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis, Nat. Commun., 6, 8363,, 2015. a
Berthault, P. and Boutin, C.: Biosensing and Study of Biological Cells using Hyperpolarized 129Xe, chap. 14, in: New Developments in NMR, edited by: Meersmann, T. and Brunner, E, Royal Society of Chemistry, Cambridge, 261–271,, 2015. a
Berthault, P., Bogaert-Buchmann, A., Desvaux, H., Huber, G., and Boulard, Y.: Sensitivity and Multiplexing Capabilities of MRI Based on Polarized 129Xe Biosensors, J. Am. Chem. Soc., 130, 16456–16457,, 2008. a
Berthault, P., Huber, G., and Desvaux, H.: Biosensing using laser-polarized xenon NMR/MRI, Prog. Nucl. Mag. Res. Sp., 55, 35–60,, 2009. a
Bodet, O., Goerke, S., Behl, N. G. R., Roeloffs, V., Zaiss, M., and Bachert, P.: Amide proton transfer of carnosine in aqueous solution studied in vitro by WEX and CEST experiments: Study of Amide Proton Transfer in Carnosine-Water System, NMR Biomed., 28, 1097–1103,, 2015. a
Short summary
The use of hyperpolarized species, i.e., species whose nuclear polarization is transiently multiplied by several orders of magnitude, can perfectly be combined with the use of benchtop NMR spectrometers. In particular, laser-polarized 129Xe, due to its large chemical shift range and the proximity of its resonance frequency to 13C, can be observed on a non-dedicated low-field spectrometer. Detection of low amounts of molecules can be achieved using NMR techniques based on chemical exchange.