Articles | Volume 2, issue 1
Research article
11 Jun 2021
Research article |  | 11 Jun 2021

129Xe ultra-fast Z spectroscopy enables micromolar detection of biosensors on a 1 T benchtop spectrometer

Kévin Chighine, Estelle Léonce, Céline Boutin, Hervé Desvaux, and Patrick Berthault


Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Comment on mr-2021-33', Ville-Veikko Telkki, 20 Apr 2021
    • AC1: 'Reply on RC1', Patrick Berthault, 21 Apr 2021
      • RC2: 'Reply on AC1', Ville-Veikko Telkki, 22 Apr 2021
        • AC2: 'Reply on RC2', Patrick Berthault, 27 Apr 2021
  • RC3: 'Comment on mr-2021-33', Alexej Jerschow, 09 May 2021
    • AC3: 'Reply on RC3', Patrick Berthault, 10 May 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Patrick Berthault on behalf of the Authors (18 May 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to corrections (31 May 2021) by Fabien Ferrage
AR by Patrick Berthault on behalf of the Authors (07 Jun 2021)  Author's response    Manuscript
Short summary
The use of hyperpolarized species, i.e., species whose nuclear polarization is transiently multiplied by several orders of magnitude, can perfectly be combined with the use of benchtop NMR spectrometers. In particular, laser-polarized 129Xe, due to its large chemical shift range and the proximity of its resonance frequency to 13C, can be observed on a non-dedicated low-field spectrometer. Detection of low amounts of molecules can be achieved using NMR techniques based on chemical exchange.