Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1ρ accordion experiments

Wernersson, Sven; Carlström, Göran; Jakobsson, Andreas; Akke, Mikael

doi:https://doi.org/10.5194/mr-2-571-2021

Articles | Volume 2, issue 2

https://doi.org/10.5194/mr-2-571-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Special issue:

Geoffrey Bodenhausen Festschrift

https://doi.org/10.5194/mr-2-571-2021

© Author(s) 2021. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 2, issue 2

Research article

|

12 Jul 2021

Research article |

| 12 Jul 2021

Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R_1ρ accordion experiments

Sven Wernersson, Göran Carlström, Andreas Jakobsson, and Mikael Akke

Data sets

Data for: Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1rho accordion experiments S. Wernersson, G. Carlström, A. Jakobsson, and M. Akke https://doi.org/10.17632/zyryxrgkc3.1

Entropy-Entropy Compensation Between the Conformational and Solvent Degrees of Freedom Fine-tunes Affinity in Ligand Binding to Galectin-3C J. Wallerstein, M. Misini Ignjatovic, R. Kumar, O. Caldararu, K. Peterson, H. Leffler, D. Logan, U. Nilsson, U. Ryde, and M. Akke https://doi.org/10.13018/BMR50283

Short summary

Multidimensional NMR relaxation experiments provide a powerful means of studying protein dynamics but typically require long acquisition times. Here, we combine two approaches that individually shorten the length of the experiment: accordion spectroscopy and non-uniform sampling (NUS). We extract relaxation rate constants by applying maximum likelihood estimation of sparse exponential modes modeled on the accordion–NUS interferograms, resulting in time savings by a factor of roughly 10.