Articles | Volume 2, issue 2
https://doi.org/10.5194/mr-2-571-2021
https://doi.org/10.5194/mr-2-571-2021
Research article
 | 
12 Jul 2021
Research article |  | 12 Jul 2021

Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1ρ accordion experiments

Sven Wernersson, Göran Carlström, Andreas Jakobsson, and Mikael Akke

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Interactive discussion

Status: closed

Comment types: AC – author | RC – referee | CC – community | EC – editor | CEC – chief editor | : Report abuse
  • RC1: 'Referee comment (Frueh)', Dominique Frueh, 28 May 2021
    • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021
  • RC2: 'Comment on mr-2021-46', Anonymous Referee #2, 30 May 2021
    • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021
  • RC3: 'Comment on mr-2021-46', Anonymous Referee #3, 08 Jun 2021
    • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021
  • EC1: 'Comment on mr-2021-46', Paul Schanda, 18 Jun 2021
    • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021
  • EC2: 'Comment on mr-2021-46', Paul Schanda, 19 Jun 2021
    • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021
  • AC1: 'Comment on mr-2021-46', Mikael Akke, 21 Jun 2021

Peer review completion

AR: Author's response | RR: Referee report | ED: Editor decision
AR by Mikael Akke on behalf of the Authors (22 Jun 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish subject to minor revisions (review by editor) (23 Jun 2021) by Paul Schanda
AR by Mikael Akke on behalf of the Authors (25 Jun 2021)  Author's response    Author's tracked changes    Manuscript
ED: Publish as is (28 Jun 2021) by Paul Schanda
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Short summary
Multidimensional NMR relaxation experiments provide a powerful means of studying protein dynamics but typically require long acquisition times. Here, we combine two approaches that individually shorten the length of the experiment: accordion spectroscopy and non-uniform sampling (NUS). We extract relaxation rate constants by applying maximum likelihood estimation of sparse exponential modes modeled on the accordion–NUS interferograms, resulting in time savings by a factor of roughly 10.