Time-domain proton-detected local-field NMR for molecular structure determination in complex lipid membranes

Wurl, Anika; Saalwächter, Kay; Mendes Ferreira, Tiago

doi:https://doi.org/10.5194/mr-4-115-2023

Articles | Volume 4, issue 1

https://doi.org/10.5194/mr-4-115-2023

© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.

https://doi.org/10.5194/mr-4-115-2023

© Author(s) 2023. This work is distributed under
the Creative Commons Attribution 4.0 License.

Articles | Volume 4, issue 1

Research article

|

12 May 2023

Research article |

| 12 May 2023

Time-domain proton-detected local-field NMR for molecular structure determination in complex lipid membranes

Anika Wurl, Kay Saalwächter, and Tiago Mendes Ferreira

Supplement

https://doi.org/10.5194/mr-4-115-2023-supplement

Data sets

Simulation data and code used for the publication in Magn. Reson. ``Time-domain proton-detected local-field NMR for molecular structure determination in complex lipid membranes'' (v1.0.0) T. Mendes Ferreira and A. Wurl https://doi.org/10.5281/zenodo.7898743

Model code and software

Simulation data and code used for the publication in Magn. Reson. ``Time-domain proton-detected local-field NMR for molecular structure determination in complex lipid membranes'' (v1.0.0) T. Mendes Ferreira and A. Wurl https://doi.org/10.5281/zenodo.7898743

Short summary

R-proton-detected local-field NMR is a powerful method to obtain structural information from biological membrane models. However, the conventional analysis of experiments, by using a Fourier transform in the indirect time-domain and reading-off splittings, is unsuitable to investigate complex systems. One then needs to model the experimental data. Fitting the experimental data with simulations that account for radiofrequency field inhomogeneity enables accurate modeling of R-PDLF data.